Substate, Matchups (BCMoore rank) @ Location
- George-Little Rock (3) vs. South O'Brien (10) @ MOC Floyd Valley
- West Fork (19) vs. Don Bosco (6) @ Clear Lake
- Dunkerton (16) vs. Edgewood-Colesburg (26) @ Independence
- Gladbrook-Reinbeck (20) vs. North Linn (1) @ Vinton-Shellsburg
- Iowa Mennonite (17) vs. Lynnville-Sully (11) @ Oskaloosa
- Grand View Christian (2) vs. Central Decatur (14) @ Indianola
- Bedford (41) vs. Council Bluffs St. Albert (5) @ Shenandoah
- IKM-Manning (29) vs. Remsen St. Mary's (4) @ Denison