I think it should be a case by case basis, though I can understand in some situations why they would want a neutral site if the distance is so great.
The obvious example would be IKM and West Lyon. Both teams really deserve a home game and it's quite the drive for IKM (or any one of the teams remaining on that side), and there wouldn't be any complaints by either side if a neutral site is selected (and to be honest, I think the State can still step in and do something about it, but they probably won't just because of the short notice of trying to set up a host).
But the other issue is that (and while you can make your own arguments about the schedule) it's an 11-0 team traveling to a 10-1 team. And that may not seem like a big deal, but it's a matter of precedent within the rule. West Lyon would've hosted even if they were 8-3 as long as those 3 losses came in non-district play. Should an 8-3 team really get to host an 11-0 team in the Quarterfinals? That's the precedent established within the rule for this round of the playoffs.
You don't want to punish teams for playing tougher schedules, but at the same time, having the option to go to a neutral site would help to eliminate some issues.
I do still think there should be home games for higher seeds, better district record, etc. Those teams have earned that opportunity to host, IMHO. Not to mention, it makes for a much better story when you get a team like D-NH or Central Decatur making a nice run while winning on the road.
And regarding Regina and Central Decatur, like I said I think it has to be a case by case thing. On one hand it is a very long road trip for the 3-seed and at this point in the playoffs, it's understandable to want to cut down on that distance. On the other hand.....they are a 3 seed. Not to come off as harsh, but they really only have themselves to blame for this situation, which is really unique to begin with since they're so far south and away from everyone else (similar to West Lyon up north). If you're the lowest seed remaining in the playoffs, you're not likely to be given any favors.